Biomaterials developed for facilitating healing outcome after anterior cruciate ligament reconstruction: Efficacy, surgical protocols, and assessments using preclinical animal models
Refereed conference paper presented and published in conference proceedings


摘要Anterior cruciate ligament (ACL) reconstruction is the recommended treatment for ACL tear in the American Academy of Orthopaedic Surgeons (AAOS) guideline. However, not a small number of cases failed because of the tunnel bone resorption, unsatisfactory bone-tendon integration, and graft degeneration. The biomaterials developed and designed for improving ACL reconstruction have been investigated for decades. According to the Food and Drug Administration (FDA) and the International Organization for Standardization (ISO) regulations, animal studies should be performed to prove the safety and bioeffect of materials before clinical trials. In this review, we first evaluated available biomaterials that can enhance the healing outcome after ACL reconstruction in animals and then discussed the animal models and assessments for testing applied materials. Furthermore, we identified the relevance and knowledge gaps between animal experimental studies and clinical expectations. Critical analyses and suggestions for future research were also provided to design the animal study connecting basic research and requirem
著者Xuan He, Ye Li, Jiaxin Gio, Jiankun Xu, Haiyue Zu, Le Huang, Michael Tim-yun Ong, Patrick Shu-hang Yung, Ling Qin
會議名稱The 41st Annual Congress of the Hong Kong Orthopaedic Association
會議地點Hong Kong
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
關鍵詞Biomaterials, Animal model, Anterior cruciate ligament reconstruction, Assessment, Translation

上次更新時間 2022-28-07 於 09:46