Biomaterials developed for facilitating healing outcome after anterior cruciate ligament reconstruction: Efficacy, surgical protocols, and assessments using preclinical animal models
Refereed conference paper presented and published in conference proceedings
香港中文大學研究人員
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摘要Anterior cruciate ligament (ACL) reconstruction is the recommended treatment for ACL tear in the American Academy of Orthopaedic Surgeons (AAOS) guideline. However, not a small number of cases failed because of the tunnel bone resorption, unsatisfactory bone-tendon integration, and graft degeneration. The biomaterials developed and designed for improving ACL reconstruction have been investigated for decades. According to the Food and Drug Administration (FDA) and the International Organization for Standardization (ISO) regulations, animal studies should be performed to prove the safety and bioeffect of materials before clinical trials. In this review, we first evaluated available biomaterials that can enhance the healing outcome after ACL reconstruction in animals and then discussed the animal models and assessments for testing applied materials. Furthermore, we identified the relevance and knowledge gaps between animal experimental studies and clinical expectations. Critical analyses and suggestions for future research were also provided to design the animal study connecting basic research and requirem
著者Xuan He, Ye Li, Jiaxin Gio, Jiankun Xu, Haiyue Zu, Le Huang, Michael Tim-yun Ong, Patrick Shu-hang Yung, Ling Qin
會議名稱The 41st Annual Congress of the Hong Kong Orthopaedic Association
會議開始日06.11.2021
會議完結日07.11.2021
會議地點Hong Kong
會議國家/地區香港
期刊名稱Biomaterials
出版年份2021
月份11
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
國際標準期刊號0142-9612
電子國際標準期刊號1878-5905
語言美式英語
關鍵詞Biomaterials, Animal model, Anterior cruciate ligament reconstruction, Assessment, Translation
