Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions
Publication in refereed journal

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其它資訊
摘要Dynamic protein-protein interactions are essential for proper cell functioning. Homo-interaction events—physical interactions between the same type of proteins—represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling pathways. Capacities of modulating protein-protein interactions with spatial and temporal resolution are greatly desired to decipher the dynamic nature of signal transduction mechanisms. The emerging optogenetic technology, based on genetically encoded light-sensitive proteins, provides promising opportunities to dissect the highly complex signaling networks with unmatched specificity and spatiotemporal precision. Here we review recent achievements in the development of optogenetic tools enabling light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways.
著者Peiyuan Huang, Zhihao Zhao, Liting Duan
期刊名稱Neural Regeneration Research
出版年份2022
月份1
卷號17
期次1
頁次25 - 30
國際標準期刊號1673-5374
語言美式英語

上次更新時間 2021-19-09 於 23:42