Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions
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AbstractDynamic protein-protein interactions are essential for proper cell functioning. Homo-interaction events—physical interactions between the same type of proteins—represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling pathways. Capacities of modulating protein-protein interactions with spatial and temporal resolution are greatly desired to decipher the dynamic nature of signal transduction mechanisms. The emerging optogenetic technology, based on genetically encoded light-sensitive proteins, provides promising opportunities to dissect the highly complex signaling networks with unmatched specificity and spatiotemporal precision. Here we review recent achievements in the development of optogenetic tools enabling light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways.
All Author(s) ListPeiyuan Huang, Zhihao Zhao, Liting Duan
Journal nameNeural Regeneration Research
Year2022
Month1
Volume Number17
Issue Number1
Pages25 - 30
ISSN1673-5374
LanguagesEnglish-United States

Last updated on 2021-27-07 at 23:58