Biodegradable Magnesium-Based Implants in Orthopedics-A General Review and Perspectives
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AbstractBiodegradable Mg-based metals may be promising orthopedic implants for treating challenging bone diseases, attributed to their desirable mechanical and osteopromotive properties. This Review summarizes the current status and future research trends for Mg-based orthopedic implants. First, the properties between Mg-based implants and traditional orthopedic implants are compared on the following aspects: in vitro and in vivo degradation mechanisms of Mg-based implants, peri-implant bone responses, the fate of the degradation products, and the cellular and molecular mechanisms underlying the beneficial effects of Mg ions on osteogenesis. Then, the preclinical studies conducted at the low weight bearing sites of animals are introduced. The innovative strategies (for example, via designing Mg-containing hybrid systems) are discussed to address the limitations of Mg-based metals prior to their clinical applications at weight-bearing sites. Finally, the available clinical studies are summarized and the challenges and perspectives of Mg-based orthopedic implants are discussed. Taken together, the progress made on the development of Mg-based implants in basic, translational, and clinical research has laid down a foundation for developing a new era in the treatment of challenging and prevalent bone diseases.
Acceptance Date20/04/2020
All Author(s) ListJia-li Wang, Jia-kun Xu, Chelsea Hopkins, Dick Ho-Kiu Chow, Ling Qin
Journal nameAdvanced Science
Year2020
Month4
Day22
Volume Number7
Issue Number8
PublisherWiley
Article number1902443
eISSN2198-3844
LanguagesEnglish-United States
