Comparative cardiovascular risk in users versus non-users of xanthine oxidase inhibitors and febuxostat versus allopurinol users
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Objectives: The aim of this study is to determine major adverse cardiovascular events (MACE) and all-cause mortality comparing between xanthine oxidase inhibitors (XOIs) and non-XOI users, and between allopurinol and febuxostat.

Methods: This is a retrospective cohort study of gout patients prescribed anti-hyperuricemic medications between 2013 and 2017 using a territory-wide administrative database. XOI users were matched 1:1 to XOI non-users using propensity scores. Febuxostat users were matched 1:3 to allopurinol users. Subgroup analyses were conducted based on colchicine use.

Results: Of the 13 997 eligible participants, 3607 (25.8%) were XOI users and 10 390 (74.2%) were XOI non-users. After propensity score matching, compared with non-users (n = 3607), XOI users (n = 3607) showed similar incidence of MACE (hazard ratio [HR]: 0.997, 95% CI, 0.879, 1.131; P>0.05) and all-cause mortality (HR = 0.972, 95% CI 0.886, 1.065, P=0.539). Febuxostat (n = 276) users showed a similar risk of MACE compared with allopurinol users (n = 828; HR: 0.672, 95% CI, 0.416, 1.085; P=0.104) with a tendency towards a lower risk of heart failure-related hospitalizations (HR = 0.529, 95% CI 0.272, 1.029; P=0.061). Concurrent colchicine use reduced the risk for all-cause mortality amongst XOI users (HR = 0.671, 95% 0.586, 0.768; P<0.001).

Conclusion: In gout patients, XOI users showed similar risk of MACE and all-cause mortality compared with non-users. Compared with allopurinol users, febuxostat users showed similar MACE and all-cause mortality risks but lower heart failure-related hospitalizations.
著者Chengsheng Ju, Rachel Wing Chuen Lai, Ka Hou Christien Li, Joshua Kai Fung Hung, Jenny C L Lai, Jeffery Ho, Yingzhi Liu, Man Fung Tsoi, Tong Liu, Bernard Man Yung Cheung, Ian Chi Kei Wong, Lai Shan Tam, Gary Tse
期刊名稱Rheumatology
出版年份2020
月份9
卷號59
期次9
出版社Oxford University Press
頁次2340 - 2349
國際標準期刊號1462-0324
電子國際標準期刊號1462-0332
語言美式英語
關鍵詞allopurinol, cardiovascular risk, febuxostat; gout, myocardial infarction, xanthine oxidase inhibitor

上次更新時間 2021-13-10 於 23:58