Collateral effect of COVID-19 pandemic on hospitalizations and clinical outcomes in gastrointestinal and liver diseases – a territory-wide observational study in Hong Kong
Refereed conference paper presented and published in conference proceedings


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摘要Background The Coronavirus Disease 2019 (COVID-19) pandemic had a huge impact on healthcare systems globally. Decline in hospital admissions for common medical emergencies was observed. We investigated its collateral effect on hospitalizations and clinical outcomes in patients with gastrointestinal (GI) and liver diseases in Hong Kong.

Methods We performed a territory-wide retrospective cohort study in Hong Kong from January 1, 2019, to May 31, 2020. Data were retrieved through Clinical Data Analysis and Reporting System. We included patients admitted to hospitals with top diagnoses of luminal GI cancers, pancreatico-hepatobiliary cancers, benign pancreaticobiliary disorders, liver diseases, non-infective enteritis and colitis, non-variceal and variceal upper gastrointestinal bleeding (UGIB). We excluded patient-based hospital admissions without emergency department attendance and length of stay equal to or shorter than one day. The primary endpoint was the total number of index hospital admissions related to these diagnoses at different time points. The secondary endpoints were in-hospital mortality, intensive care unit admission, elective or emergency operations and endoscopy. The COVID-19 period was defined as the time after the first local case in January 2020, week 4.

Results We recorded a total of 195,867 hospital admissions related to GI diseases during the study period, and 125,049 of them were included in the final analysis. Comparing the same pre-COVID19 and COVID-19 periods, we observed a significant decline in the average number of hospitalizations for GI diseases (17.0% reduction, P <0.001). (Figure 1) In-hospital mortality did not differ significantly (11.2% vs 11.7%, P = 0.063). Overall ICU admission rate was static (5.3% vs 5.1%, P = 0.218). More emergency endoscopies were performed in patients with UGIB (30.0% vs 38.9%, P <0.001) and benign pancreaticobiliary conditions (17.5% vs 24.4%, P <0.001). Higher proportion of patients underwent emergency operations during their hospitalization (6.7% vs 8.0%, P <0.001).

Conclusions The number of hospitalizations related to GI diseases reduced drastically during the COVID-19 epidemic, yet no excessive in-hospital mortality was observed. More emergency endoscopies and operations were required, particularly for UGIB and benign pancreaticobiliary conditions.
著者Lau HSL, Wong HS, Lui ARNS, Yip TCF, Tang SYR, Wong LHG, Wong WSV, Sung JYJ
會議名稱International-Digestive-Disease-Forum (IDDF)
會議開始日22.11.2020
會議完結日23.11.2020
會議地點Hong Kong
會議國家/地區香港
會議論文集題名Gut
出版作品名稱GUT
出版年份2020
月份11
卷號69
期次Suppl 2
出版社BMJ PUBLISHING GROUP
頁次A45 - A46
國際標準期刊號0017-5749
語言英式英語
Web of Science 學科類別Gastroenterology & Hepatology;Gastroenterology & Hepatology

上次更新時間 2022-15-01 於 23:39