Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity
Publication in refereed journal

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摘要Transforming growth factor-β (TGF-β) was originally identified as an anti-tumour cytokine. However, there is increasing evidence that it has important roles in the tumour microenvironment (TME) in facilitating cancer progression. TGF-β actively shapes the TME via modulating the host immunity. These actions are highly cell-type specific and complicated, involving both canonical and non-canonical pathways. In this review, we systemically update how TGF-β signalling acts as a checkpoint regulator for cancer immunomodulation. A better appreciation of the underlying pathogenic mechanisms at the molecular level can lead to the discovery of novel and more effective therapeutic strategies for cancer.
著者Xue VW, Chung JY, Córdoba CAG, Cheung AH, Kang W, Lam EW, Leung KT, To KF, Lan HY, Tang PM
期刊名稱Cancers
詳細描述Corresponding Author: Tang Ming-kuen, Patrick
出版年份2020
月份11
卷號12
期次11
出版社MDPI
文章號碼3099
國際標準期刊號2072-6694
語言英式英語

上次更新時間 2021-13-10 於 00:15