Quantitative T1 rho MRI of the Head and Neck Discriminates Carcinoma and Benign Hyperplasia in the Nasopharynx
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AbstractBACKGROUND AND PURPOSE: T1 rho imaging is a new quantitative MR imaging pulse sequence with the potential to discriminate between malignant and benign tissue. In this study, we evaluated the capability of T1 rho imaging to characterize tissue by applying T1 rho imaging to malignant and benign tissue in the nasopharynx and to normal tissue in the head and neck.MATERIALS AND METHODS: Participants with undifferentiated nasopharyngeal carcinoma and benign hyperplasia of the nasopharynx prospectively underwent T1 rho imaging. T1 rho measurements obtained from the histogram analysis for nasopharyngeal carcinoma in 43 participants were compared with those for benign hyperplasia and for normal tissue (brain, muscle, and parotid glands) in 41 participants using the Mann-Whitney U test. The area under the curve of significant T1 rho measurements was calculated and compared using receiver operating characteristic analysis and the Delong test, respectively. A P<.05 indicated statistical significance.RESULTS: There were significant differences in T1 rho measurements between nasopharyngeal carcinoma and benign hyperplasia and between nasopharyngeal carcinoma and normal tissue (all, P<.05). Compared with benign hyperplasia, nasopharyngeal carcinoma showed a lower T1 rho mean (62.14 versus 65.45 x ms), SD (12.60 versus 17.73 x ms), and skewness (0.61 versus 0.76) (all P<.05), but no difference in kurtosis (P=.18). The T1 rho SD showed the highest area under the curve of 0.95 compared with the T1 rho mean (area under the curve = 0.72) and T1 rho skewness (area under the curve = 0.72) for discriminating nasopharyngeal carcinoma and benign hyperplasia (all, P<.05).CONCLUSIONS: Quantitative T1 rho imaging has the potential to discriminate malignant from benign and normal tissue in the head and neck.
Acceptance Date07/08/2020
All Author(s) ListAi QYH, Chen W, So TY, Lam WKJ, Jiang B, Poon DMC, Qamar S, Mo FKF, Blu T, Chan Q, Ma BBY, Hui EP, Chan KCA, King AD
Journal nameAmerican Journal of Neuroradiology
Volume Number41
Issue Number12
Pages2339 - 2344
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesClinical Neurology;Neuroimaging;Radiology, Nuclear Medicine & Medical Imaging;Neurosciences & Neurology;Radiology, Nuclear Medicine & Medical Imaging

Last updated on 2021-13-10 at 00:17