Engineering multi-tissue units for regenerative Medicine: Bone-tendon-muscle units of the rotator cuff
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AbstractOur body systems are comprised of numerous multi-tissue units. For the musculoskeletal system, one of the predominant functional units is comprised of bone, tendon/ligament, and muscle tissues working in tandem to facilitate locomotion. To successfully treat musculoskeletal injuries and diseases, critical consideration and thoughtful integration of clinical, biological, and engineering aspects are necessary to achieve translational bench-to-bedside research. In particular, identifying ideal biomaterial design specifications, understanding prior and recent tissue engineering advances, and judicious application of biomaterial and fabrication technologies will be crucial for addressing current clinical challenges in engineering multi-tissue units. Using rotator cuff tears as an example, insights relevant for engineering a bone-tendon-muscle multi-tissue unit are presented. This review highlights the tissue engineering strategies for musculoskeletal repair and regeneration with implications for other bone-tendon-muscle units, their derivatives, and analogous non-musculoskeletal tissue structures.
Acceptance Date26/03/2021
All Author(s) ListDan Wang, Xu Zhang, Shuting Huang, Yang Liu, Bruma Sai-chuen Fu, Kingston King-lun Mak, Anna Maria Blocki, Patrick Shu-hang Yung, Rocky S.Tuan, Dai Fei Elmer Ker
Journal nameBiomaterials
Year2021
Month5
Volume Number272
PublisherElsevier
Article number120789
ISSN0142-9612
eISSN1878-5905
LanguagesEnglish-United Kingdom
KeywordsMusculoskeletal tissue engineering, Rotator cuff repair, Biomaterials, Stem cells, Growth factors, Extracellular matrix