Altered cortico-striatal functional connectivity in people with high levels of schizotypy: A longitudinal resting-state study
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AbstractPurpose of the research: Cortico-striatal functional connectivity has been implicated in the neuropathology of schizophrenia. However, the longitudinal relationship between the cortico-striatal connectivity and schizotypy remains unknown. We examined the resting-state fMRI connectivity in 27 individuals with a high level of schizotypy and 20 individuals with a low level of schizotypy at baseline and 18 months later. Correlations between changes in cortico-striatal connectivity and changes in schizotypy scores over time were examined.

Principal results: We found both increased and decreased cortico-striatal connectivity in individuals with a high level of schizotypy at baseline. Over time, these individuals showed improvement in both the negative and positive schizotypal domains. Changes in striatal-insula connectivity were positively correlated with changes in positive schizotypy from baseline to follow-up.

Major conclusions: Our results suggested impaired cortico-striatal connectivity in individuals with a high level of schizotypy. The dysconnectivity mainly involves the dorsal striatum. The connectivity between the dorsal striatum and the insula may be a putative marker for temporal changes in positive schizotypy.
All Author(s) ListWang L-L, Sun X., Chiu C-D., Leung P.W.L., Chan R.C.K., So S.H.
Journal nameAsian Journal of Psychiatry
Volume Number58
Article number102621
LanguagesEnglish-United States

Last updated on 2021-08-06 at 00:04