Evaluation of bronchial challenge test results for use in assessment of paediatric eczema: a retrospective series
Publication in refereed journal

Times Cited
Altmetrics Information

Other information
AbstractBackground: Atopic dermatitis (AD), asthma, and allergic rhinitis are associated diseases involved in the atopic march. The bronchial challenge test (BCT) is a tool that evaluates airway hyperresponsiveness in patients with asthma. This study aimed to evaluate whether a positive BCT result is useful in assessment of paediatric AD.
Methods: This retrospective case series included 284 patients with AD who had BCT results. Clinical information and laboratory parameters were reviewed, including AD severity (using the SCORing Atopic Dermatitis [SCORAD]), skin hydration, and transepidermal water loss.
Results: Of the 284 patients who had BCT, 106 had positive BCT results and 178 had negative BCT results. A positive BCT result was associated with a history of asthma (P<0.0005), sibling with asthma (P=0.048), serum immunoglobulin E (P=0.045), eosinophil count (P=0.017), and sensitisation to food allergens in the skin prick test (P=0.027). There was no association between a positive BCT result and personal allergic rhinitis, parental atopy, sibling allergic rhinitis or AD, skin prick response to dust mites, objective SCORAD score, skin hydration, transepidermal water loss, exposure to smoking, incense burning, cat or dog ownership, or AD treatment aspects (eg, food avoidance and traditional Chinese medicine). Logistic regression showed significant associations of a positive BCT result with a history of asthma (adjusted odds ratio=4.05; 95% confidence interval=1.92-8.55; P<0.0005) and sibling atopy (adjusted odds ratio=2.25; 95% confidence interval=1.03-4.92; P=0.042).
Conclusions: In patients with paediatric AD, a positive BCT result was independently and positively associated with personal history of asthma and sibling history of atopy, but not with any other clinical parameters.
Acceptance Date01/02/2021
All Author(s) ListKL Hon, Abraham HY Ng, Chrystal CC Chan, Prisca XY Ho, Emma PM Tsoi, Kathy YC Tsang, Fanny W Ko, TF Leung
Journal nameHong Kong Medical Journal
Volume Number27
Issue Number1
PublisherHong Kong Academy of Medicine
Place of PublicationHong Kong
Pages27 - 34
LanguagesEnglish-United Kingdom
KeywordsEczema, airway hyperreactivity, bronchial provocation, children

Last updated on 2021-22-06 at 00:14