Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis induced by ovariectomy in a rat model
Publication in refereed journal


Times Cited
Web of Science0WOS source URL (as at 18/06/2021) Click here for the latest count
Altmetrics Information
.

Other information
AbstractAntiresorptive drugs are effective for reducing bone loss in postmenopausal women, but their long-term application may be associated with adverse effects. The present study aimed to investigate the potential in vivo synergistic effects of green tea extract (GTE) and alendronate or raloxifene on the management of osteoporosis. Ovariectomized rats were fed orally with GTE, alendronate and raloxifene at different concentrations and various combinations for 4 weeks. Bone mineral density (BMD) at the lumbar spine, femur and tibia was monitored weekly using peripheral quantitative computed tomography. Bone microarchitecture in the left distal femur was analyzed using micro-CT, while serum biochemical levels were measured using ELISA kits at the end of the study. GTE alone effectively mitigated BMD loss and improved bone microarchitecture in rats. The co-administration of GTE and alendronate increased total BMD in the lumbar spine, femur and tibia. Particularly, GTE synergistically enhanced the effect of alendronate at a low dose on bone microarchitecture and decreased serum tartrate-resistant acid phosphatase. These findings imply that the dosage of certain antiresorptive agents could be reduced when they are administrated simultaneously with GTE, so that their adverse effects are minimized. The findings may be used to support the development of a new synergistic intervention between food therapy and pharmacotherapy on the management of osteoporosis in a long-term basis.
All Author(s) ListSiu WS, Ko CH, Shiu HT, Li KK, Shum WT, Leung PC, Zhang JF
Journal nameExperimental and Therapeutic Medicine
Year2021
Month4
Volume Number21
Issue Number4
PublisherSPANDIDOS PUBL LTD
Article number328
ISSN1792-0981
eISSN1792-1015
LanguagesEnglish-United Kingdom
Keywordsgreen tea, raloxifene, alendronate, osteoporosis, antiresorptive
Web of Science Subject CategoriesMedicine, Research & Experimental;Research & Experimental Medicine

Last updated on 2021-19-06 at 00:27