Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis induced by ovariectomy in a rat model
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摘要Antiresorptive drugs are effective for reducing bone loss in postmenopausal women, but their long-term application may be associated with adverse effects. The present study aimed to investigate the potential in vivo synergistic effects of green tea extract (GTE) and alendronate or raloxifene on the management of osteoporosis. Ovariectomized rats were fed orally with GTE, alendronate and raloxifene at different concentrations and various combinations for 4 weeks. Bone mineral density (BMD) at the lumbar spine, femur and tibia was monitored weekly using peripheral quantitative computed tomography. Bone microarchitecture in the left distal femur was analyzed using micro-CT, while serum biochemical levels were measured using ELISA kits at the end of the study. GTE alone effectively mitigated BMD loss and improved bone microarchitecture in rats. The co-administration of GTE and alendronate increased total BMD in the lumbar spine, femur and tibia. Particularly, GTE synergistically enhanced the effect of alendronate at a low dose on bone microarchitecture and decreased serum tartrate-resistant acid phosphatase. These findings imply that the dosage of certain antiresorptive agents could be reduced when they are administrated simultaneously with GTE, so that their adverse effects are minimized. The findings may be used to support the development of a new synergistic intervention between food therapy and pharmacotherapy on the management of osteoporosis in a long-term basis.
著者Siu WS, Ko CH, Shiu HT, Li KK, Shum WT, Leung PC, Zhang JF
期刊名稱Experimental and Therapeutic Medicine
出版年份2021
月份4
卷號21
期次4
出版社SPANDIDOS PUBL LTD
文章號碼328
國際標準期刊號1792-0981
電子國際標準期刊號1792-1015
語言英式英語
關鍵詞green tea, raloxifene, alendronate, osteoporosis, antiresorptive
Web of Science 學科類別Medicine, Research & Experimental;Research & Experimental Medicine

上次更新時間 2021-07-05 於 23:39