Risk of dispersion or aerosol generation and infection transmission with nasopharyngeal and oropharyngeal swabs for detection of COVID-19: a systematic review
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AbstractObjectives: SARS-CoV-2-related disease, referred to as COVID-19, has emerged as a global pandemic since December 2019. While there is growing recognition regarding possible airborne transmission, particularly in the setting of aerosol-generating procedures and treatments, whether nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 generate aerosols remains unclear.

Design: Systematic review.

Data sources: We searched Ovid MEDLINE and EMBASE up to 3 November 2020. We also searched the China National Knowledge Infrastructure, Chinese Medical Journal Network, medRxiv and ClinicalTrials.gov up to 29 March 2020.

Eligibility criteria: All comparative and non-comparative studies that evaluated dispersion or aerosolisation of viable airborne organisms, or transmission of infection associated with nasopharyngeal or oropharyngeal swab testing.

Results: Of 7702 citations, only one study was deemed eligible. Using a dedicated sampling room with negative pressure isolation room, personal protective equipment including N95 or higher masks, strict sterilisation protocols, structured training with standardised collection methods and a structured collection and delivery system, a tertiary care hospital proved a 0% healthcare worker infection rate among eight nurses conducting over 11 000 nasopharyngeal swabs. No studies examining transmissibility with other safety protocols, nor any studies quantifying the risk of aerosol generation with nasopharyngeal or oropharyngeal swabs for detection of SARS-CoV-2, were identified.

Conclusions: There is limited to no published data regarding aerosol generation and risk of transmission with nasopharyngeal and oropharyngeal swabs for the detection of SARS-CoV-2. Field experiments to quantify this risk are warranted. Vigilance in adhering to current standards for infection control is suggested.
All Author(s) ListAgarwal A, Fernando SM, Honarmand K, Bakaa L, Brar S, Granton D, Chaudhuri D, Chetan D, Hu M, Basmaji J, Muttalib F, Rochwerg B, Adhikari NKJ, Lamontagne F, Murthy S, Hui DS, Gomersall CD, Mubareka S, Diaz J, Burns KE, Couban R, Vandvik PO
Journal nameBMJ Open
Volume Number11
Issue Number3
PublisherBMJ Publishing Group
Place of PublicationEngland
LanguagesEnglish-United Kingdom
KeywordsDiagnostic microbiology, Infection control, Public health

Last updated on 2021-20-06 at 23:58