An update on the roles of circular RNAs in osteosarcoma
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摘要Osteosarcoma is the most common primary bone malignancy and is a neoplasm thought to be derived from the bone-forming mesenchymal stem cells. Aberrant activation of oncogenes and inactivation of tumour suppressor genes by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. Aside from alterations in these protein-coding genes, it has now been realized that dysregulation of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma. CircRNAs are single-stranded RNAs that form covalently closed loops and function as an important regulatory element of the genome through multiple machineries. Recently, an increasing number of studies suggested that circRNAs also played critical roles in osteosarcoma. This review summarizes recent development and progression in circRNA transcriptome analysis and their functions in the modulation of osteosarcoma progression.
出版社接受日期04.10.2020
著者Li Z, Li X, Xu D, Chen X, Li S, Zhang L, Chan MTV, Wu WKK
版次e12936
期刊名稱Cell Proliferation
出版年份2021
月份1
卷號54
期次1
出版社John Wiley & Sons Ltd.
文章號碼e12936
國際標準期刊號0960-7722
電子國際標準期刊號1365-2184
語言英式英語
關鍵詞CircRNAs, CircTCF25, ncRNAs, osteosarcoma, CircRNAs
