An update on the roles of circular RNAs in osteosarcoma
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AbstractOsteosarcoma is the most common primary bone malignancy and is a neoplasm thought to be derived from the bone-forming mesenchymal stem cells. Aberrant activation of oncogenes and inactivation of tumour suppressor genes by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. Aside from alterations in these protein-coding genes, it has now been realized that dysregulation of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma. CircRNAs are single-stranded RNAs that form covalently closed loops and function as an important regulatory element of the genome through multiple machineries. Recently, an increasing number of studies suggested that circRNAs also played critical roles in osteosarcoma. This review summarizes recent development and progression in circRNA transcriptome analysis and their functions in the modulation of osteosarcoma progression.
Acceptance Date04/10/2020
All Author(s) ListLi Z, Li X, Xu D, Chen X, Li S, Zhang L, Chan MTV, Wu WKK
Journal nameCell Proliferation
Volume Number54
Issue Number1
PublisherJohn Wiley & Sons Ltd.
Article numbere12936
LanguagesEnglish-United Kingdom
KeywordsCircRNAs, CircTCF25, ncRNAs, osteosarcoma, CircRNAs

Last updated on 2022-15-01 at 00:14