Biomaterials developed for facilitating healing outcome after anterior cruciate ligament reconstruction: Efficacy, surgical protocols, and assessments using preclinical animal models
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AbstractAnterior cruciate ligament (ACL) reconstruction is the recommended treatment for ACL tear in the American Academy of Orthopaedic Surgeons (AAOS) guideline. However, not a small number of cases failed because of the tunnel bone resorption, unsatisfactory bone-tendon integration, and graft degeneration. The biomaterials developed and designed for improving ACL reconstruction have been investigated for decades. According to the Food and Drug Administration (FDA) and the International Organization for Standardization (ISO) regulations, animal studies should be performed to prove the safety and bioeffect of materials before clinical trials. In this review, we first evaluated available biomaterials that can enhance the healing outcome after ACL reconstruction in animals and then discussed the animal models and assessments for testing applied materials. Furthermore, we identified the relevance and knowledge gaps between animal experimental studies and clinical expectations. Critical analyses and suggestions for future research were also provided to design the animal study connecting basic research and requirements for future clinical translation.
All Author(s) ListHe X., Li Y., Guo J., Xu J., Zu H., Huang L., Tim-yun Ong M., Shu-hang Yung P., Qin L.
Journal nameBiomaterials
Year2021
Month2
Volume Number269
PublisherElsevier Ltd
Article number120625
ISSN0142-9612
eISSN1878-5905
LanguagesEnglish-United Kingdom
KeywordsAnimal model, Anterior cruciate ligament reconstruction, Assessment, Biomaterials, Translation
