Autophagy signals orchestrate chemoresistance of gynecological cancers
Publication in refereed journal

替代計量分析
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其它資訊
摘要Gynecological cancers are characterized by a high mortality rate when chemoresistance develops. Autophagy collaborates with apoptosis and participates in homeostasis of chemoresistance. Recent findings supported that crosstalk of necrotic, apoptotic and autophagic factors, and chemotherapy-driven hypoxia, oxidative stress and ER stress play critical roles in chemoresistance in gynecological cancers. Meanwhile, current studies have shown that autophagy could be regulated by and cooperate with metabolic regulator, survival factors, stemness factors and specific post-translation modification in chemoresistant tumor cells. Meanwhile, non-coding RNA and autophagy crosstalk also contribute to the chemoresistance. Until now, analysis of individual autophagy factors towards the clinical significance and chemoresistance in gynecological cancer is still lacking. We suggest comprehensive integrated analysis of cellular homeostasis and tumor microenvironment to clarify the role of autophagy and the associated factors in cancer progression and chemoresistance. Panel screening of pan-autophagic factors will pioneer the development of risk models for predicting efficacy of chemotherapy and guidelines for systematic treatment and precision medicine.
出版社接受日期12.02.2021
著者Chit Tam, Shitao Rao, Mary Miu Yee Waye, Tzi Bun Ng, Chi Chiu Wang
期刊名稱Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
出版年份2021
月份4
卷號1875
期次2
出版社Elsevier
文章號碼188525
國際標準期刊號0304-419X
電子國際標準期刊號0006-3002
語言英式英語
關鍵詞Autophagy, Chemoresistance, Epigenetic control, Metabolic regulation

上次更新時間 2021-16-06 於 00:10