Effectiveness of Scutellaria barbata water extract on inhibiting colon tumor growth and metastasis in tumor-bearing mice
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AbstractThe plant Scutellaria barbata (SB) is commonly used as herbal medicines for treating cancer. The present pre-clinical study aimed to validate the Chinese Pharmacopoeia (CP) recommended dosages of SB water extract (SBW) in treating colon tumors. The content of chemical marker scutellarin in SBW was quantified using UPLC. Mice bearing human HCT116 xenografts or murine colon26 tumors received oral administration of SBW or scutellarin for 4 weeks. Results showed that SBW (615 and 1,230 mg/kg) and scutellarin (7 mg/kg) treatments significantly reduced human xenograft weights by 28.7, 36.9 and 28.8%, respectively. Lung metastasis area could be ameliorated after SBW (615 mg/kg) and scutellarin (7 mg/kg) treatments by 23.4 and 29.5%, respectively. Expressions of colon cancer metastasis-related proteins E-cadherin, Tspan 8 and CXCR4, as well as Src kinase in tumors were first shown to be regulated by SBW. Furthermore, in murine colon26 tumor-bearing mice, SBW (615 mg/kg) and scutellarin (7 mg/kg) treatments reduced the orthotopic tumor burden by 94.7% and lung metastatic tumor burden by 94.1%, respectively. Our findings provided evidences that SBW (at the mouse equivalent dosages to clinical dosages recommended by CP) could exert anti-tumor and anti-metastatic effects in colon cancer animal models.
All Author(s) ListYue GGL, Chan YY, Liu WJ, Gao S, Wong CW, Lee JKM, Lau KM, Lau CBS
Journal namePhytotherapy Research
Year2021
Month1
Volume Number35
Issue Number1
PublisherWILEY
Pages361 - 373
ISSN0951-418X
eISSN1099-1573
LanguagesEnglish-United Kingdom
Keywordschemical marker, colon cancer, metastasis, Scutellaria barbata, scutellarin
Web of Science Subject CategoriesChemistry, Medicinal;Pharmacology & Pharmacy;Pharmacology & Pharmacy

Last updated on 2021-16-06 at 00:10