Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice
Publication in refereed journal

替代計量分析
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其它資訊
摘要SIRT3 has been speculated to affect osteoclast activity through its important roles in regulating mitochondrial function. It remains unclear whether SIRT3 affects osteoclast activity in female mice which is relevant to postmenopausal osteoporosis. We hypothesized that deletion of SIRT3 could modulate bone remodeling in female mice under physiological aging process or ovariectomy (OVX)-induced bone loss. We found that SIRT3 level was markedly increased in primary bone marrow-derived macrophages (BMMs) from both 26-month-old aged mice and OVX mice. Knockdown of SIRT3 in vitro inhibited osteoclast differentiation and mitochondrial biogenesis, and deletion of SIRT3 increased trabecular bone mass in female mice due to impaired osteoclastogenesis. The effect of SIRT3 on bone remodeling appears to be age-dependent as revealed by comparing the effect of SIRT3 deletion on 5-week-old, 3-month-old and 6-month-old female mice. Interestingly, Sirt3-/- mice were more resistant to bone loss following estrogen deficiency resulting from OVX. Our findings demonstrated that SIRT3 could play critical roles in bone remodeling and estrogen deficiency-induced bone loss in female mice, suggesting that SIRT3 and its downstream effectors might be potential novel therapeutic targets for the management of postmenopausal osteoporosis.
著者Qiangqiang Li, Haixing Wang, Jiajun Zhang, Alice Pik-Shan Kong, Gang Li, Tsz-Ping Lam, Jack Chun-Yiu Cheng, Wayne Yuk-Wai Lee
期刊名稱BONE
出版年份2021
月份3
卷號144
出版社Elsevier
文章號碼115827
國際標準期刊號8756-3282
電子國際標準期刊號1873-2763
語言英式英語
關鍵詞Aging, Ovariectomy, Osteoclast, Osteoporosis, SIRT3

上次更新時間 2021-24-09 於 23:55