Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors
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AbstractA facile approach to assemble catalase‐like photosensitizing nanozymes with a self‐oxygen‐supplying ability was developed. The process involved Fe3+‐driven self‐assembly of fluorenylmethyloxycarbonyl (Fmoc)‐protected amino acids. By adding a zinc(II) phthalocyanine‐based photosensitizer (ZnPc) and the hypoxia‐inducible factor 1 (HIF‐1) inhibitor acriflavine (ACF) during the Fe3+‐promoted self‐assembly of Fmoc‐protected cysteine (Fmoc‐Cys), the nanovesicles Fmoc‐Cys/Fe@Pc and Fmoc‐Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe3+ could catalyze the transformation of H2O2 enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc‐Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc‐Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.
Acceptance Date03/09/2020
All Author(s) ListYongxin Li, Pan Sun, Luyang Zhao, Xuehai Yan, Dennis K. P. Ng, Pui-Chi Lo
Journal nameAngewandte Chemie International Edition
Year2020
Month12
Volume Number59
Issue Number51
PublisherWiley
Pages23228 - 23238
ISSN1433-7851
eISSN1521-3773
LanguagesEnglish-United Kingdom
Keywordscatalase, hypoxia, photodynamic therapy, phthalocyanine, self-assembly

Last updated on 2021-27-02 at 23:24