Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors
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摘要A facile approach to assemble catalase‐like photosensitizing nanozymes with a self‐oxygen‐supplying ability was developed. The process involved Fe3+‐driven self‐assembly of fluorenylmethyloxycarbonyl (Fmoc)‐protected amino acids. By adding a zinc(II) phthalocyanine‐based photosensitizer (ZnPc) and the hypoxia‐inducible factor 1 (HIF‐1) inhibitor acriflavine (ACF) during the Fe3+‐promoted self‐assembly of Fmoc‐protected cysteine (Fmoc‐Cys), the nanovesicles Fmoc‐Cys/Fe@Pc and Fmoc‐Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe3+ could catalyze the transformation of H2O2 enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc‐Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc‐Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.
出版社接受日期03.09.2020
著者Yongxin Li, Pan Sun, Luyang Zhao, Xuehai Yan, Dennis K. P. Ng, Pui-Chi Lo
期刊名稱Angewandte Chemie International Edition
出版年份2020
月份12
卷號59
期次51
出版社Wiley
頁次23228 - 23238
國際標準期刊號1433-7851
電子國際標準期刊號1521-3773
語言英式英語
關鍵詞catalase, hypoxia, photodynamic therapy, phthalocyanine, self-assembly

上次更新時間 2021-10-04 於 23:54