Magnesium-pretreated periosteum for promoting bone-tendon healing after anterior cruciate ligament reconstruction
Publication in refereed journal

替代計量分析
.

其它資訊
摘要Periosteum can improve tendon-bone healing when applied to wrap the tendon graft in both animal studies and clinical trials. As magnesium (Mg) ions can significantly elevate the levels of relevant cytokines involving in the osteogenic differentiation of periosteum-derived stem cells, the Mg-pretreated periosteum may be an innovative approach for enveloping the tendon graft. To test this hypothesis, we compared the effects of Mg-pretreated periosteum (M − P) and the stainless steel (SS)-pretreated periosteum (SS–P) in ACL reconstruction. We firstly found that the released Mg ions from the Mg implants were partially accumulated in periosteum, resulting in higher Mg/Ca ratio in the M − P compared to the SS-P. Additionally, the M − P showed significantly higher expression levels of calcitonin gene-related peptide (CGRP) and periostin than the SS-P due to the decrease in Cathepsin K (CTSK). Elevation of CGRP and periostin was beneficial for the osteogenic differentiation of periosteum-derived stem cells. More importantly, we demonstrated that the M − P remarkably increased the formation of fibrocartilage at the interface between the periosteum and tendon. Collectively, M − P group demonstrated significantly prevented peri-tunnel bone loss, more osseous ingrowth into the tendon graft and higher maximum load to failure as compared to the SS-P group. In summary, our study warrants further investigations for translating the current proof-of-concept findings to optimize the delivery of CGRP, periostin, and cells as novel practical therapeutic strategy for enhancing tendon-bone interface healing in patients undergoing ACL reconstruction.
出版社接受日期21.11.2020
著者Jiali Wang, Jiankun Xu, Xinluan Wang, Liyuan Sheng, Lizhen Zheng, Bin Song, Ge Wu, Ri Zhang, Hao Yao, Nianye Zheng, Michael Tim Yun Ong, Patrick Shu-hang Yung, Ling Qin
期刊名稱Biomaterials
出版年份2021
月份1
卷號268
出版社Elsevier
文章號碼120576
國際標準期刊號0142-9612
電子國際標準期刊號1878-5905
語言美式英語
關鍵詞ACL reconstruction, CGRP, Magnesium, Periosteum, Macrophages

上次更新時間 2021-30-07 於 23:56