SARS-CoV-2 infection in children - Understanding the immune responses and controlling the pandemic
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AbstractIn December 2019, a cluster of patients with severe pneumonia caused by a novel coronavirus (SARS-CoV-2) emerged in the city of Wuhan, China. The disease is now termed coronavirus disease 2019 (COVID-19). In the early reports, the patients were mainly middle-aged and elderly men, and children appeared to be less susceptible to this infection. With modern and efficient transportation, the disease quickly spread to almost all corners of the world and the mortality far exceeds that caused by severe acute respiratory syndrome (SARS) coronavirus or Middle East respiratory syndrome (MERS) coronavirus. As the number of children with COVID-19 gradually increases, the disease has been documented in premature babies, infants, children, and adolescents. Severe and fatal cases in children are relatively rare. The burden of disease in children has been relatively low, but the high proportions of asymptomatic or mildly symptomatic infections in children deserve careful attention. A clear understanding of the immune responses to the virus in children and the transmission potential of asymptomatic children is of paramount importance for the development of specific treatments and vaccine in order to effectively control the ongoing pandemic.
Acceptance Date21/04/2020
All Author(s) ListXiaoxia Lu, Yun Xiang, Hui Du, Gary Wing-Kin Wong
Journal namePediatric Allergy and Immunology
Detailed descriptionTS Lo Foundation Funding
Volume Number31
Issue Number5
PublisherJohn Wiley and Sons Ltd
Place of PublicationGermany
Pages449 - 453
LanguagesEnglish-United Kingdom
Keywordschildren, coronavirus, immune response, pandemic, SARS-CoV-2

Last updated on 2021-18-09 at 00:03