Extracellular Vesicles in Head and Neck Cancer: A Potential New Trend in Diagnosis, Prognosis, and Treatment
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摘要Head and neck cancer (HNC) is a fatal and debilitating disease that is characterized by steady, poor survival rates despite advances in treatment. There is an urgent and unmet need to improve our understanding of what drives this insidious cancer and causes poor outcomes. Extracellular vesicles (EVs) are small vesicles that originate from tumor cells, immune cells, and other cell types and are secreted into plasma, saliva, and other bio-fluids. EVs represent dynamic, real-time changes of cells and offer an exciting opportunity to improve our understanding of HNC biology that may translate to improved clinical practice. Considering the amplified interest in EVs, we have sought to provide a contemporary review of the most recent and salient literature that is shaping the field. Herein, we discuss the functionality of EVs in HNCs and their clinical potential with regards to biomarker and therapeutic capabilities.
著者Xinyu Qu, Jing-Woei Li, Jason Chan, Katie Meehan
期刊名稱International Journal of Molecular Sciences
出版年份2020
月份11
卷號21
期次21
出版社MDPI
文章號碼8260
國際標準期刊號1661-6596
語言美式英語
關鍵詞extracellular vesicles; head and neck cancer; diagnosis; therapy

上次更新時間 2021-27-02 於 23:18