Association of serum 25(OH)Vit-D Levels with risk of paediatric fractures: a systematic review and meta-analysis
Refereed conference paper presented and published in conference proceedings


摘要Introduction: Vitamin D (Vit-D) insufficiency is highly prevalent in the paediatric population. This study aimed to review
the literature on the association between serum 25(OH)Vit-D levels and the risks of fractures in children and adolescents, and to explore the sources of heterogeneity on reported results.

Materials and Methods: Systematic review and meta-analysis for observational studies comparing serum Vit-D levels
between fracture and non-fracture paediatric cases were conducted. Results: Analysis on 15 case-control and five cross-sectional studies reported before 24 February 2020 and involving a total of 7184 subjects (2709 fracture cases and 4475 controls) suggested that serum 25(OH)Vit-D was lower in fracture cases than in controls (pooled mean difference (MD): -3.28 nmol/L; 95% confidence interval (CI): -5.67 to -0.89). The pooled MD were -15.18 nmol/L (95% CI: -20.60 to -9.76) and 1.61 nmol/L (95% CI: -6.33 to 9.54) in summer and in winter, respectively. Rate of Vit-D deficiency (25(OH)Vit-D<50 nmol/L) was higher in fracture cases than in controls (pooled odds ratio=1.25; 95% CI: 1.06-1.48; p=0.01). Rate of Vit-D insufficiency (25(OH)Vit-D between 52.5 and 72.5 nmol/L) was similar between fractures cases and controls (pooled odds ratio=1.13; 95% CI: 0.78-1.63; p=0.53).

Discussion and Conclusion: This systematic review indicated that serum 25(OH)Vit-D levels were lower in children
with fractures, particularly in summer. Children with fractures were more likely to have 25(OH)Vit-D levels less than
50 nmol/L.
著者Guang Pu Yang, Tsz Ping Lam, Wayne Yuk Wai Lee, Alec Lik Hang Hung, Man Fung Tang, Patrick Shu Hang Yung,
Jack Chun Yiu Cheng
會議名稱Hong Kong Orthopaedic Association 40th Annual Congress 2020 (HKOA 2020)
會議地點Hong Kong
出版地Hong Kong

上次更新時間 2021-06-01 於 10:30