Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus
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摘要Objectives: Two labdane diterpenoids, leojapone B and heteronone B, were isolated from Leonurus japonicus Houtt., and their biological activity were evaluated in this study.

Methods: Human and mouse cancer cells, human peripheral blood mononuclear cells (PBMCs) and mouse macrophages (RAW264.7 cells) were used to evaluate the activity of leojapone B and heteronone B, while the in vivo effects of leojapone B were further examined in Lewis Lung Cancer tumour-bearing mice.

Key findings: In vitro studies showed that leojapone B selectively inhibited the proliferation of lung cancer cells, and both leojapone B and heteronone B inhibited the production of pro-inflammatory cytokines in activated PBMCs. In tumour-bearing mice model, lung tumours were reduced in size in mice treated with intraperitoneal injections of leojapone B at 20 and 30 mg/kg for 14 days. The population ratio of CD4+ /CD8+ T cells in mouse spleens was found to be increased, while regulatory T cells were decreased after leojapone B treatment.

Conclusions: The inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components in L. japonicus.
著者Yue GG, Liang XX, Li XL, Lee JK, Gao S, Kwok HF, Lau CB, Xiao WL
期刊名稱Journal of Pharmacy and Pharmacology
出版年份2020
月份11
卷號72
期次11
出版社Wiley
頁次1657 - 1665
國際標準期刊號0022-3573
電子國際標準期刊號2042-7158
語言英式英語

上次更新時間 2021-17-09 於 00:26