Rational Design of a Reversible Mg2+/EDTA-controlled Molecular Switch Based on a DNA Minidumbbell
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AbstractHere we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.
Acceptance Date16/07/2020
All Author(s) ListLiqi Wan, Sik Lok Lam, Hung Kay Lee, Pei Guo
Journal nameChemical Communications
Volume Number56
Issue Number70
PublisherRoyal Society of Chemistry
Place of PublicationUK
Pages10127 - 10130
LanguagesEnglish-United States

Last updated on 2021-18-09 at 00:05