Digital Micromirror Device Based Angle-multiplexed Optical Diffraction Tomography for High Throughput 3D Imaging of Cells
Refereed conference paper presented and published in conference proceedings


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AbstractThe development of high throughput three-dimensional (3D) microscopic imaging technique is important for studying cell physiology and early-stage disease diagnoses. Here we propose and demonstrate a digital micromirror device (DMD) based angle-multiplexed high-speed optical diffraction tomography (ODT) technique. Using this ODT technique, we have achieved 3D imaging of cells at over 600 tomogram/second speed, which is 10-100 times faster than current ODT-based 3D cell imaging techniques. We envision that this high-speed ODT system will enable many cutting-edge biomedical applications, such as capturing millisecond scale cell dynamics in 3D space and high throughput 3D imaging of large cell populations.
Acceptance Date28/02/2020
All Author(s) ListYanping He, Yijin Wang, Renjie Zhou
Name of ConferenceSPIE Photonics West
Start Date of Conference04/02/2020
End Date of Conference06/02/2020
Place of ConferenceSan Francisco
Country/Region of ConferenceUnited States of America
Proceedings TitleSPIE Photonics West
Title of PublicationEMERGING DIGITAL MICROMIRROR DEVICE BASED SYSTEMS AND APPLICATIONS XII
Year2020
Month2
Day28
Volume Number11294
PublisherSPIE
Article number1129402
ISSN0277-786X
LanguagesEnglish-United States
KeywordsOptical diffraction tomography, digital micromirror device, refractive-index mapping, high throughput imaging
Web of Science Subject CategoriesOptics;Optics

Last updated on 2021-14-06 at 00:03