Suppression of the Hippo Pathway in Tubular Cells Leads to Renal Fibrosis in Mice
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摘要Background
The Hippo pathway controls organ size and tumorigenesis. The core components of the Hippo pathway consist of Mammalian Ste20-like kinases 1/2 (MST1/2) and their scaffold protein SAV1, large tumor suppressor 1/2 (LATS1/2) and their scaffold proteins MOB1A/1B, and two downstream effectors YAP/TAZ. Several components of the Hippo pathway, including SAV1, LATS1/2, and YAP/TAZ, have been found to be critically involved in embryonic kidney development or kidney disease. However, the role of MST1 and MST2 in kidney remains unknown.
著者Chunhua Xu, Yang Wang, Li Wang, King Lun Kingston Mak, Yu Huang, Yin Xia
會議名稱ASN Kidney Week 2019
會議開始日05.11.2019
會議完結日10.11.2019
會議地點Washington DC
會議國家/地區美國
出版年份2019
月份11
日期5
文章號碼TH-PO478
語言美式英語

上次更新時間 2020-23-11 於 16:32