Suppression of the Hippo Pathway in Tubular Cells Leads to Renal Fibrosis in Mice
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AbstractBackground
The Hippo pathway controls organ size and tumorigenesis. The core components of the Hippo pathway consist of Mammalian Ste20-like kinases 1/2 (MST1/2) and their scaffold protein SAV1, large tumor suppressor 1/2 (LATS1/2) and their scaffold proteins MOB1A/1B, and two downstream effectors YAP/TAZ. Several components of the Hippo pathway, including SAV1, LATS1/2, and YAP/TAZ, have been found to be critically involved in embryonic kidney development or kidney disease. However, the role of MST1 and MST2 in kidney remains unknown.
All Author(s) ListChunhua Xu, Yang Wang, Li Wang, King Lun Kingston Mak, Yu Huang, Yin Xia
Name of ConferenceASN Kidney Week 2019
Start Date of Conference05/11/2019
End Date of Conference10/11/2019
Place of ConferenceWashington DC
Country/Region of ConferenceUnited States of America
Year2019
Month11
Day5
Article numberTH-PO478
LanguagesEnglish-United States

Last updated on 2020-23-11 at 16:32