A natural flavone tricin from grains can alleviate tumor growth and lung metastasis in colorectal tumor mice
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AbstractTricin, a flavone isolated from rice bran, has been shown to be chemopreventive in a colorectal cancer (CRC) mouse model. This study aimed to illustrate the inhibitory activities of tricin in colon cancer cells and in a metastatic CRC mouse model. BALB/c mice injected with mouse Colon26-Luc cells into the rectum wall were treated with tricin (37.5 mg/kg) daily for 18 days. Orthotopic colon tumor growth and metastasis to lungs were assessed by in vivo bioluminescence imaging. Results showed that tricin suppressed Colon-Luc cells motility and downregulated phosphorylated Akt, Erk1/2 and NF-κB expressions of human colon cancer HT-29 cells. While tricin treatment suppressed tumor growth and lung metastasis as well as altered the populations of myeloid-derived suppressor cells and regulatory T cells in spleens. In summary, the tumor microenvironment modulatory and anti-metastatic effects of tricin in colon cancer mouse model were shown for the first time, suggesting the potential development of tricin-containing food supplements for CRC patients.
Acceptance Date13/08/2020
All Author(s) ListYue GGL, Gao S, Lee JKM, Chan YY, Wong ECW, Zheng T, Li XX, Shaw PC, Simmonds MSJ, Lau CBS
Journal nameMolecules
Volume Number25
Issue Number16
Article number3730
LanguagesEnglish-United Kingdom

Last updated on 2021-12-06 at 01:24