Advances in optical mapping for genomic research
Publication in refereed journal

替代計量分析
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其它資訊
摘要Recent advances in optical mapping have allowed the construction of improved genome assemblies with greater contiguity. Optical mapping also enables genome comparison and identification of large-scale structural variations. Association of these large-scale genomic features with biological functions is an important goal in plant and animal breeding and in medical research. Optical mapping has also been used in microbiology and still plays an important role in strain typing and epidemiological studies. Here, we review the development of optical mapping in recent decades to illustrate its importance in genomic research. We detail its applications and algorithms to show its specific advantages. Finally, we discuss the challenges required to facilitate the optimization of optical mapping and improve its future development and application.
著者Yuxuan Yuan, Claire Yik-Lok Chung, Ting-Fung Chan
期刊名稱Computational and Structural Biotechnology Journal
出版年份2020
月份8
卷號18
出版社Elsevier
頁次2051 - 2062
國際標準期刊號2001-0370
語言美式英語
關鍵詞Optical mapping, Genome assembly, Structural variation, Next generation sequencing

上次更新時間 2020-28-11 於 00:00