Anti-diabetic effects of Edgeworthia chrysantha and Edgeworthia gardneri flower buds – An ethnic herbal tea in China
Publication in refereed journal


摘要Introduction: Edgeworthia chrysantha (EC) flower buds are consumed as tea by Tujia ethnic group in China. Owing to the close phytological origin and similar appearance, EC is believed to possess anti-diabetic effect like the related species Edgeworthia gardneri (EG).

Methods: This study aimed to test the hypothesis that EC aqueous extract was as potent as EG aqueous extract in lowering basal and postprandial plasma glucose levels of diabetic mice. The chemical profiles of the two extracts were also analyzed using ultra performance liquid chromatography.

Results: We found that EC aqueous extract contained 1.311 % of tiliroside and 0.032 % of daphnoretin, whereas EG aqueous extract contained 0.660 % of tiliroside and 0.226 % of daphnoretin. Neither edgeworin nor quercetin were detected in both extracts. Animal experiments demonstrated that EC and EG aqueous extracts at 200mg/kg (converted from human daily dose) were not potent in lowering basal plasma glucose levels of diabetic mice after 14-day treatment. However, a single oral dose of 200 mg/kg of EC or EG aqueous extract possessed mild antihyperglycemic effect in diabetic mice subjected to oral glucose tolerance test.

Conclusion: In conclusion, EC was of similar potency as EG and can be considered as an alternative of EG in diabetes management.
著者Lau KM, Wong CW, Long CL, Lau CBS
期刊名稱Biomedical Journal of Scientific & Technical Research
出版社Biomedical Research Network
頁次21986 - 21992
國際標準期刊號2574 -1241

上次更新時間 2021-19-09 於 23:32