Protective effects of Sulforaphene against Amyloid β-Induced Neurotoxicity in Vitro and in Vivo Models of Alzheimer’s Disease
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摘要Alzheimer ’s Disease (AD) is a most common form of neurocognitive disorder and affect about 50 million people worldwide. AD is characterized by progressive loss of memory and decline of cognitive functions due to neuronal death mainly in the hippocampal and cortical brain. Although the pathogenesis of AD is complicated and multifaceted, there are two classical pathological hallmarks, including extra-neuronal accumulation of amyloid plaques composed of β-amyloid peptide (Aβ) and intraneuronal deposits of neurofibrillatory tangles (NFT). Sulforaphane (SFN) and sulforaphene (SF) are the main isothiocyanates of Raphani Semen. SNF has been described as an anti-oxidant and an anti-inflammatory agent and has been reported to have potent neuroprotective effects. Previous studies have proved that SFN could reduce the cognitive impairments in several animal models of AD. Since SF has the similar chemical structure to SFN, we hypothesize that SF may have anti-AD effects in the experimental models of AD. In this study, we explored whether SF had anti-AD effects using Aβ 1-42-treated primary neuron cells and rats. The results showed that SF treatment reduced the neurotoxicity induced by Aβ 1-42 in primary neuronal cells and improved the cognitive deficits induced by Aβ 1-42 in rats assessing by Morris water Maze task. Moreover, the gene expressions of brain derived neurotrophic factor (BDNF) and cytokines such as tumor necrosis factor (TNF-α), interlocking 6 (IL-6) and IL-1beta (IL-1β) were regulated by SF. The current studies provided scientific evidence to support the possible development of SF as a potential therapeutic agent for treatment and prevention of AD.
著者Wen Yang, Yan-Fang Xian, Zhi-Xiu Lin
會議名稱The 15th International Postgraduate Symposium on Chinese Medicine (IPSCM)
會議開始日16.08.2019
會議完結日16.08.2019
會議地點Hong Kong
會議國家/地區香港
出版年份2019
月份8
語言英式英語

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