Honokiol, Magnolol and Their Combination Ameliorate Cognitive Impairments in TgCRND8 Transgenic Mice via Modulating Neuroinflammation and Synaptic Dysfunction
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摘要Alzheimer’s Disease (AD) is a neurodegenerative disease manifested by progressive memory loss and cognitive decline. Accumulating evidence suggests the extracellular deposition of senile plaques formed by beta-amyloid (Aβ), intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein and loss of neuronal synapses occurs in the early stage of AD pathogenesis and is associated with cognitive decline. Currently drugs for AD can only ameliorate symptoms of AD but are unable to reverse or even slow down the diseases process. Therefore, effective treatment for AD clearly remains an unmet medical need.
Traditional Chinese Medicine (TCM) may offer therapies with better efficacy and fewer side-effects. Magnolia officinalis (Hou-Po) is a herb frequently prescribed in herbal formulae for treating dementia in Chinese medicine. Previous studies demonstrated that honokiol and magnolol were the main active ingredients of M. officinalis, and they had anti-AD effects in vitro and in vivo models of AD. In this study, we aimed to explore whether honokiol, magnolol and their combination could improve the cognitive deficits in TgCRND8 transgenic mice and their action mechanisms.
Male mice were divided into 6 groups (n=10): wild type (WT) group, TgCRND8 mice vehicle control group, Tg + honokiol (20mg/kg) group, Tg + magnolol (20mg.kg) group, Tg + honokiol (10mg/kg) + magnolol (10mg/kg) group, Tg + Donepezil (5mg/kg) group. Drugs were given orally daily for consecutive 90 days. After drug treatment, radial arm maze test was used to assess the improving cognitive deficits effect of honokiol, magnolol and their combination. After the behavior test, mice were sacrificed and brain tissue were harvested for further study.
Our result showed that the protein levels of PSD93, PSD-95, synapsin-1, IL-6, IL-10 and IL-1β, as well as the microglia were significantly increased in the brain tissue of TgCRND8 mice. Treatment with honokiol, magnolol and their combination could markedly reversed these changes in the brain tissues of TgCRND8 mice.
著者Chang Qu, Yan-Fang Xian, Zhi-Xiu Lin
會議名稱The 15th International Postgraduate Symposium on Chinese Medicine (IPSCM)
會議地點Hong Kong

上次更新時間 2020-20-11 於 16:26