Extracellular Matrix Remodeling During Palate Development
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要The morphogenesis of the mammalian secondary plate is a series of highly dynamic developmental process, including the palate shelves vertical outgrowth, elevation to the horizontal plane and complete fusion in the midline. Extracellular matrix (ECM) proteins not only form the basic infrastructure for palatal mesenchymal cells to adhere via integrins but also interact with cells to regulate their functions such as proliferation and differentiation. ECM remodeling is essential for palatal outgrowth, expansion, elevation, and fusion. Multiple signaling pathways important for palatogenesis such as FGF, TGF β, BMP, and SHH remodels ECM dynamics. Dysregulation of ECM such as HA synthesis or ECM breakdown enzymes MMPs or ADAMTS causes cleft palate in mouse models. A better understanding of ECM remodeling will contribute to revealing the pathogenesis of cleft palate.
出版社接受日期19.02.2020
著者WANG Xia, LI Chunman, ZHU Zeyao, YUAN Li, CHAN Wood Yee, SHA Ou
期刊名稱Organogenesis
出版年份2020
月份4
卷號16
期次2
出版社Taylor and Francis Inc.
頁次43 - 60
國際標準期刊號1547-6278
電子國際標準期刊號1555-8592
語言英式英語
關鍵詞cleft palate, development, ECM, morphogenesis, remodeling

上次更新時間 2021-24-01 於 00:31