Prevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community
Publication in refereed journal


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其它資訊
摘要Objectives
We conducted a cross-sectional study in Hong Kong community to estimate the carriage prevalence, associated factors and genotypes of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA) and carbapenemase-producing Enterobacteriaceae (CPE).

Methods
Seemingly healthy subjects were asked to provide nasal, handprint and stool samples from March to April 2017. Isolates were characterized by molecular methods. We used multivariable logistic regression models within a generalized estimating equation framework to identify risk factors for ESBL-E carriage. Characteristics of MRSA/CPE carriage were summarized.

Results
The prevalence of ESBL-E, MRSA and CPE were 52.8% (104/197), 2.5% (5/197) and 0.5% (1/197) respectively. Most ESBL-E isolates were E. coli (85.6%; 113/132). Most ESBL genes belonged to blaCTX−M-G9 (68.9%) and blaTEM (53.0%) types. Self-reported antibiotic consumption (≥2 courses) in the past six months was associated with ESBL-E carriage (adjusted odds ratio: 4.71–5.47).

Conclusions
Abundance of ESBL-E in the community are causes of concern, and antibiotic use is associated with its carriage. Presence of MRSA and CPE in community members without clear healthcare exposure hints on a change in their epidemiology. This study establishes a baseline to formulate infection control policies and future studies in combating antimicrobial resistance.
出版社接受日期17.05.2020
著者Kin-On Kwok, Emily Chan, Pui-Hong Chung, Arthur Tang , Wan-In Wei, Chendi Zhu, Steven Riley, Margaret Ip
期刊名稱Journal of Infection
出版年份2020
月份8
卷號81
期次2
出版社Elsevier
頁次242 - 247
國際標準期刊號0163-4453
電子國際標準期刊號1532-2742
語言美式英語
關鍵詞Multidrug resistance, Extended spectrum beta-lactamase, Methicillin-resistant, Carbapenemase, Community prevalence

上次更新時間 2021-21-01 於 00:20