Independent and Opposing Associations of Habitual Exercise and Chronic PM2.5 Exposures on Hypertension Incidence
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摘要BACKGROUND:
We investigated the joint associations of habitual physical activity (PA) and long-term exposure to fine particulate matter (PM2.5) with the development of hypertension in a longitudinal cohort in Taiwan.

METHODS:
We selected 140 072 adults (≥18 years of age) without hypertension who joined a standard medical screening program with 360 905 medical examinations between 2001 and 2016. PM2.5 exposure was estimated at each participant’s address using a satellite data-based spatiotemporal model with 1 km2 resolution. Information on habitual
PA and a wide range of covariates was collected using a standard self administered questionnaire. We used the Cox regression model with time dependent covariates to examine the joint associations.

RESULTS:
The mean age of all observations was 41.7 years, and 48.8% were male. The mean value for systolic and diastolic blood pressure was 112.5 and 68.7mm Hg, respectively. Approximately 34.2% of all observations were inactive (0 metabolic equivalence values-hours), 29.8% had moderate-PA (median [interquartile range]; 3.75 [3.38 to 4.38]
metabolic equivalence values-hours), and 36.0% had high-PA (15.7 [10.3 to 24.8] metabolic equivalence values-hours). The mean±SD of PM2.5 was 26.1±7.3 μg/m3. The prevalence of cardiovascular disease, diabetes mellitus,
and cancer was 2.1%, 2.9%, and 1.5%, respectively. After adjusting for a wide range of covariates (including a mutual adjustment for PA or PM2.5), a higher PA level was associated with a lower risk of hypertension (hazard
ratio [HR] for the moderate- and high-PA was 0.93 [95% CI, 0.89–0.97] and 0.92 [95% CI, 0.88–0.96], respectively, as compared with the inactive-PA), whereas a higher level of PM2.5 was associated with a higher risk of
hypertension (HR for the moderate- and high-PM2.5 was 1.37 [95% CI, 1.32–1.43] and 1.92 [95% CI, 1.81–2.04], respectively, as compared with the low-PM2.5 group]. No significant interaction was observed between PA
and PM2.5 (HR 1.01 [95% CI, 1.00–1.02]).

CONCLUSIONS:
A high-PA and low PM2.5 exposure were associated with a lower risk of hypertension. The negative association between PA and hypertension remained stable in people exposed to various levels of PM2.5, and the positive association between PM2.5 and hypertension was not modified by PA. Our results indicated that PA is a suitable hypertension prevention strategy for people residing in relatively polluted regions.
出版社接受日期10.06.2020
著者Guo C, Zeng YQ, Chang LY, Yu ZG, Bo YC, Lin CQ, Lau AKH, Tam T, Lao XQ
期刊名稱Circulation
出版年份2020
月份8
卷號142
期次7
出版社American Heart Association
頁次645 - 656
國際標準期刊號0009-7322
電子國際標準期刊號1524-4539
語言英式英語
關鍵詞ambient particulate matter, cohort studies, hypertension, physical activity, Taiwan

上次更新時間 2021-23-02 於 00:11