lncFunTK: A Toolkit for Functional Annotation of Long Noncoding RNAs
Publication in policy or professional journal

替代計量分析
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其它資訊
摘要Motivation
Thousands of long noncoding RNAs (lncRNAs) were newly identified from high throughput RNA-seq data. Functional annotation and prioritization of these lncRNAs for further experimental validation as well as the functional investigation is the bottleneck step for many noncoding RNA studies.

Results
Here we describe lncFunTK that can run either as standard application or webserver for this purpose. It integrates high throughput sequencing data (i.e. ChIP-seq, CLIP-seq and RNA-seq) to construct the regulatory network associated with lncRNAs. Through the network, it calculates the Functional Information Score (FIS) of each individual lncRNA for prioritizing and inferring its functions through Gene Ontology (GO) terms of neighboring genes. In addition, it also provides utility scripts to support the input data preprocessing and the parameter optimizing. We further demonstrate that lncFunTK can be widely used in various biological systems for lncRNA prioritization and functional annotation.
出版社接受日期01.10.2018
著者Jiajian Zhou, Yile Huang, Yingzhe Ding, Jie Yuan, Huating Wang, Hao Sun
期刊名稱Bioinformatics
出版年份2018
月份10
日期1
卷號34
期次19
出版社Oxford University Press
出版地USA
頁次3415 - 3416
國際標準期刊號1367-4803
電子國際標準期刊號1460-2059
語言美式英語

上次更新時間 2021-26-02 於 23:49