Persistence and clearance of oral human papillomavirus infections: a prospective population-based cohort study
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This study aimed to evaluate the incidence of and factors associated with persistence and clearance of oral HPV infections.

A prospective cohort study invited 458 subjects (231 HPV-positive and 227 HPVnegative at baseline) to attend follow-ups at 12-months. Those 231 HPV-positive subjects and 10 new infections were invited to reassessment at 24-months. We used Next-Gen Sequencing for detection and genotyping of HPV.

Alpha-HPV infections showed higher persistence rates than Beta/Gamma-HPV (22.7% vs. 9.2% at 12 months [p<0.05], 10.6% vs. 6.8% at 24 months [p=0.30]). Clearance rates of Alpha- HPV were lower than Beta/Gamma-HPV at 12 months (31.8% vs. 45.1%, p=0.05) and higher at 24 months (7.6% vs. 4.8%, p=0.36). Persistence of Beta/Gamma-HPV was positively associated with males (Crude Odds Ratio[COR]=3.8, 95% CI=1.3-11.2), elderly (51-65 vs. 16-50 years) (COR=5.1, 95% CI=1.2-22.3), and smoking (COR=4.3, 95% CI=1.9-9.6). Drinking (COR=0.5, 95% CI=0.3-0.9), handwashing <90% of times before meals (COR=0.6, 95% CI=0.3-0.9), and using public bath >1 per month (COR=0.5, 95% CI=0.2-0.9) were risk factors hindering Beta/Gamma-HPV clearance.

This study identified factors associated with persistence and clearance of oral HPV infections among Chinese. Studies on other ethno-geographic groups may further inform prevention strategies of oral HPV infection and immunisation programmes.
Acceptance Date31/05/2020
All Author(s) ListMartin CS Wong, Alexander C Vlantis, Miaoyin Liang, Po Yee Wong, Wendy CS Ho, Siaw S Boon, Colette Leung, Paul KS Chan, Zigui Chen
Journal nameJournal of Medical Virology
Volume Number92
Issue Number12
Pages3807 - 3814
LanguagesEnglish-United Kingdom
Keywordsclearance, oral HPV infection, persistence, risk factors

Last updated on 2021-17-09 at 00:25