One of the culprits of hepatic sinusoidal obstruction syndrome in China - pyrrolizidine alkaloid N-oxides
Refereed conference paper presented and published in conference proceedings


摘要Pyrrolizidine alkaloids (PAs) are phytotoxins widely distributed in plant species and one of the major causes for inducing hepatic sinusoidal obstruction syndrome (HSOS). PAs induce HSOS via metabolic activation to form reactive metabolites, which bind with cellular proteins to generate pyrrole-protein adducts, leading to hepatotoxicity. PA N-oxides coexist with their corresponding PAs in plants. However, PA N-oxides are used to be considered as less/or not toxic, because in the body PAs are also biotransformed to their corresponding N-oxides, which resulted in less PAs to be generated to reactive metabolites. Recently, we, for the first time, found PA N-oxides as the sole or predominant form of PAs in 23 herbs ingested by patients in China and confirmed PA N-oxides-induced HSOS in human. Using animal models, we further confirmed PA N-oxide-induced hepatotoxicity and delineated the toxic mechanism. In this presentation, our study of PA N-oxide-induced HSOS from identification of clinical problems, to laboratory basic science for delineating toxic mechanism and developing biomarker, and then transformation of the biomarker for clinical diagnosis will be illustrated. [The study was supported by GRF Grants (Ref Nos.: 14106318 and 14160817) and CUHK Direct Grant (Ref Nos.: 4054503)
著者G. LIN, J. MA, M.B. Yang, Y. Yang
會議名稱6th GRIDD/SIMM Annual Symposium and Griffith-China Research Symposium

上次更新時間 2020-26-11 於 12:21