Association of real-time PM2.5 exposure with decrease of blood oxygen saturation in COPD patient
Refereed conference paper presented and published in conference proceedings


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AbstractBackground/Aim
Numerous epidemiologic studies have demonstrated the associations of particulate matter air pollution with increase of cardiopulmonary morbidity and mortality. Pollution-related hypoxia has been proposed as one of the underlying mechanisms through which pollution might increase the risk of cardiorespiratory events; however, few evidence of pollution-related hypoxia has been revealed. The exacerbation of chronic obstructive pulmonary diseases (COPD) always associates with deteriorating gas exchange, which could lower blood oxygen saturation and possibly further cause hypoxia. In the current study, we aimed to investigate the acute effect of fine particulate matter (PM2.5) exposure on the peripheral capillary oxygen saturation (SpO2) in a panel study of twenty non-smoking old participants with COPD.

Methods
Real-time PM2.5 exposure and SpO2 for each participant were measured and averaged continually every 5 minutes during 3-day repeated-measures by a portable MicroPEMTM sensor and a wireless ring pulse oximeter, respectively. We applied linear mixed-effect model to analyse the association of acute PM2.5 exposure with the mean change of SpO2, by adding the identity number of each subject as random-effect intercept and PM2.5 exposure as fixed effect, while adjusting for potential confounding factors of personal characteristics and the simultaneously measured temperature and relative humidity. We examined the exposure-response relationship curves and explored the lag patterns of PM2.5 exposure (multiple moving average of PM2.5 exposures preceding SpO2 measurements) in its acute effects.

Results
We observed the linear relationship between PM2.5 and SpO2, and the statistically significant negative associations of PM2.5 exposure at various lag hours with mean change of SpO2 (%). An interquartile range (IQR) increase of real-time PM2.5 exposure at preceding 0-3 hour (17.6 µg/m3) was associated with a -0.38 (95%CI: -0.50, -0.26) decrease of SpO2 (%), and the corresponding effect size tended to be greater at night-time than in daytime (-0.79 vs. -0.34).

Conclusions
The reduction in blood oxygen saturation in COPD patients might be associated with real-time exposure to fine particulate matter air pollution. Further air quality management and personal protection approaches are needed among vulnerable populations.
All Author(s) ListQiu H, Xia X, Kwok TCY, Ho KF
Name of ConferenceThe Joint Meeting of Asian Chapters of International Society for Environmental Epidemiology and the International Society of Exposure Science (ISEE-ISES AC2019)
Start Date of Conference16/10/2019
End Date of Conference19/10/2019
Place of ConferenceDaegu, South Korea
Country/Region of ConferenceSouth Korea
Year2019
LanguagesEnglish-United States

Last updated on 2020-27-11 at 09:36