Synthesis and In Vitro Photodynamic Activity of Cationic Boron Dipyrromethene-Based Photosensitizers Against Methicillin-Resistant Staphylococcus aureus
Publication in refereed journal


摘要A series of cationic boron dipyrromethene (BODIPY) derivatives were synthesized and characterized with various spectroscopic methods. Having the ability to generate singlet oxygen upon irradiation, these compounds could potentially serve as photosensitizers for antimicrobial photodynamic therapy. Of the five BODIPYs being examined, the dicationic aza-BODIPY analogue (compound 5) demonstrated the highest potency against a broad spectrum of clinically relevant methicillin-resistant Staphylococcus aureus (MRSA), including four ATCC-type strains (ATCC 43300, ATCC BAA-42, ATCC BAA-43, and ATCC BAA-44), two strains carrying specific antibiotic resistance
mechanisms [-AAC(6’)-APH(2”) and RN4220/pUL5054], and ten non-duplicate clinical strains from hospital- and community-associated MRSAs of the important clonal types ST239, ST30, and ST59, which have previously been documented to be prevalent in Hong Kong and its neighboring countries. The in vitro anti-MRSA activity of compound 5 was achieved upon irradiation with near-infrared light (>610 nm) with minimal bactericidal concentrations (MBCs) ranging from 12.5 to 25 μM against the whole panel of MRSAs, except the hospital-associated MRSAs for which the MBCs were in the range of 50–100 μM. Compound 5 was significantly (p < 0.05) more potent than methylene blue,
which is a clinically approved photosensitizer, indicating that it is a promising antimicrobial agent that is worthy of further investigation.
著者Priyanga DHARMARATNE, Roy C H WONG, Jun WANG, Pui-Chi LO, Baiyan WANG, Ben C L CHAN, Kit-Man LAU, Clara B S LAU, Kwok-Pui FUNG, Margaret IP, Dennis K P NG
關鍵詞antimicrobials, boron dipyrromethenes, methicillin-resistant Staphylococcus aureus, photodynamic therapy, photosensitizers

上次更新時間 2021-13-10 於 23:57