Organelle Biogenesis and Biogenesis in Plants
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AbstractOrganelle biogenesis and function is an important topic in plant cell biology. The plant endomembrane system contains several functionally distinct organelles including the endoplasmic reticulum (ER), Golgi apparatus, trans-Golgi network (TGN) or early endosome prevacuolar compartment (PVC) or multivesicular body (MVB), and vacuole [1]. Over the past years, we have used a combination of cellular, molecular, genetic approaches and 3D TEM approaches to study protein trafficking, biogenesis and function of several organelles in the plant endomembrane system, with novel findings: 1) We demonstrated a unique mechanism of COPII-mediated ER protein export [2]; 2) We showed multiple functional roles of FREE1 (a plant-unique ESCRT component) in mediating MVB biogenesis and MVB-autophagosome fusion as as well as autophagosome biogenesis [3-5]; 3) We developed a new strategy to screen for suppressor of free1 [6] and identified a novel mechanism in which a BRo1-domain protein As FREE1 suppressor (BRAF) was shown to negatively regulate MVB biogenesis and MVB-mediated protein sorting in plants [7]; 4) Using 3D whole-cell tomography analysis, we developed a new model of vacuole formation in Arabidopsis root cells [8]. Here, I will present an update on our research progress in these areas. Supported by grants from the Research Grants Council of Hong Kong (CUHK14100818, C4011-14R, C4012-16E, C4002-17G, R4005-18 and AoE/M-05/12), CUHK and the National Natural Science Foundation of China (31670179, and 91854201).
All Author(s) ListLiwen Jiang
Name of Conference18th International Workshop on Plant Membrane Biology
Start Date of Conference07/07/2019
End Date of Conference12/07/2019
Place of ConferenceGlasgow
Country/Region of ConferenceGreat Britain
Year2019
Month7
Day7
LanguagesEnglish-United Kingdom

Last updated on 2020-18-09 at 15:28