Upconversion and downconversion nanoparticles for biophotonics and nanomedicine
Publication in refereed journal


摘要In the last decade, upconversion and downconversion nanoparticles (UCNPs and DCNPs) have exhibited attractive unique optical properties and are used in various fields, including photonics, energy and chemical engineering. They recently showed potential in biophotonics and nanomedicine research, such as ultrasensitive biosensing and light-controlled cancer therapy. This review first summarizes the synthesis, chemical and optical properties and the functionalization of different UCNPs and DCNPs, and then focuses on recent advances in employing functional UCNPs and DCNPs for bio-imaging and -sensing in disease diagnostics. It also highlights the in-depth research of UCNPs and DCNPs for nanomedicine applications, especially both in vitro and in vivo cancer therapy, such as light-controlled drug and gene delivery. Finally, it provides concluding perspectives, challenges and future directions on the use of UCNPs and DCNPs in biomedical and clinical research. The objective of this review is to introduce UCNPs and DCNPs available in biomedical research to the general readers to facilitate further research and development of both fundamental sciences and applications.
著者Loo Jacky Fong-Chuen, Chien Yi-Hsin, Yin Feng, Kong Siu-Kai, Ho Ho-Pui, Yong Ken-Tye
期刊名稱Coordination Chemistry Reviews
關鍵詞Upconversion nanoparticles, Downconversion nanoparticles, Biosensing, Nanomedicine, Photodynamic therapy, Cancer theranostics

上次更新時間 2020-23-11 於 23:45