MRI of benign hyperplasia in the nasopharynx: is there an association with Epstein–Barr virus?
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AbstractAIM
To evaluate whether there is an association between persistently positive plasma Epstein–Barr virus (EBV) DNA and the presence and the change in benign hyperplasia.

MATERIALS AND METHODS
One hundred and seventeen participants with positive-plasma EBV-DNA, but without NPC from previous nasopharyngeal carcinoma (NPC) screening, underwent follow-up magnetic resonance imaging (MRI) and plasma EBV-DNA after 2 years. Logistic regression was used to analyse associations between MRI (benign hyperplasia on the follow-up MRI and change from 2 years earlier), and plasma EBV-DNA, smoking, and age.

RESULTS
At follow-up, EBV-DNA positivity and smoking were independent parameters for the presence of benign hyperplasia (p=0.027 and 0.023 respectively). Compared with participants in whom EBV-DNA became negative (n=44/117 37.6%), those in whom EBV-DNA remained positive (n=73/117 62.4%) had a greater risk of benign hyperplasia developing (previous MRI normal), being stable or processing (52/73 71.2% versus 18/44 40.9%; p=0.001).

CONCLUSION
These results suggest a potential link between benign hyperplasia on MRI and the EBV. As EBV contributes to NPC oncogenesis, future MRI research is warranted to determine if persistent benign hyperplasia is a risk marker for development of NPC.
Acceptance Date07/05/2020
All Author(s) ListAi QY, King AD, So TY, Lam WKJ, Mo FKF, Tse IOL, Woo JKS, Chan KCA
Journal nameClinical Radiology
Year2020
Month9
Volume Number75
Issue Number9
PublisherElsevier
Pages711.e13 - 711.e18
ISSN0009-9260
eISSN1365-229X
LanguagesEnglish-United States
Keywordsbenign hyperplasia, Epstein-Barr virus (EBV), magnetic resonance imaging

Last updated on 2020-26-10 at 00:12