MRI of benign hyperplasia in the nasopharynx: is there an association with Epstein–Barr virus?
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To evaluate whether there is an association between persistently positive plasma Epstein–Barr virus (EBV) DNA and the presence and the change in benign hyperplasia.

One hundred and seventeen participants with positive-plasma EBV-DNA, but without NPC from previous nasopharyngeal carcinoma (NPC) screening, underwent follow-up magnetic resonance imaging (MRI) and plasma EBV-DNA after 2 years. Logistic regression was used to analyse associations between MRI (benign hyperplasia on the follow-up MRI and change from 2 years earlier), and plasma EBV-DNA, smoking, and age.

At follow-up, EBV-DNA positivity and smoking were independent parameters for the presence of benign hyperplasia (p=0.027 and 0.023 respectively). Compared with participants in whom EBV-DNA became negative (n=44/117 37.6%), those in whom EBV-DNA remained positive (n=73/117 62.4%) had a greater risk of benign hyperplasia developing (previous MRI normal), being stable or processing (52/73 71.2% versus 18/44 40.9%; p=0.001).

These results suggest a potential link between benign hyperplasia on MRI and the EBV. As EBV contributes to NPC oncogenesis, future MRI research is warranted to determine if persistent benign hyperplasia is a risk marker for development of NPC.
Acceptance Date07/05/2020
All Author(s) ListAi QY, King AD, So TY, Lam WKJ, Mo FKF, Tse IOL, Woo JKS, Chan KCA
Journal nameClinical Radiology
Volume Number75
Issue Number9
Pages711.e13 - 711.e18
LanguagesEnglish-United States
Keywordsbenign hyperplasia, Epstein-Barr virus (EBV), magnetic resonance imaging

Last updated on 2021-23-09 at 23:48