Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health
Publication in policy or professional journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Heightened activity of osteoclast is considered to be the culprit in breaking the balance during bone remodeling in pathological conditions, such as osteoporosis. As a “foe” of skeletal health, many antiosteoporosis therapies aim to inhibit osteoclastogenesis. However, bone remodeling is a dynamic process that requires the subtle coordination of osteoclasts and osteoblasts. Severe suppression of osteoclast differentiation will impair bone formation because of the coupling effect. Thus, understanding the complex roles of osteoclast in maintaining proper bone remodeling is highly warranted to develop better management of osteoporosis. This review aimed to determine the varied roles of osteoclasts in maintaining skeletal health and to highlight the positive roles of osteoclasts in maintaining normal bone remodeling. Generally, osteoclasts interact with osteocytes to initiate targeted bone remodeling and have crosstalk with mesenchymal stem cells and osteoblasts via secreted factors or cell-cell contact to promote bone formation. We believe that a better outcome of bone remodeling disorders will be achieved when proper strategies are made to coordinate osteoclasts and osteoblasts in managing such disorders.
出版社接受日期27.01.2020
著者Haixing Wang, Guangpu Yang, Yinbo Xiao, Guotian Luo, Gang Li, Ziqing Li
期刊名稱BioMed Research International
出版年份2020
月份3
日期4
卷號2020
出版社Hindawi
文章號碼4791786
頁次1 - 10
國際標準期刊號2314-6133
電子國際標準期刊號2314-6141
語言美式英語
關鍵詞Factor secreted by osteoclasts, Effect on Bone remodeling

上次更新時間 2020-22-11 於 00:16