Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors
Publication in refereed journal

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摘要Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in the world. It is a heterogeneous disease characterized by genetic and epigenetic aberrations. The TP53 mutation is the key step driving the transition from adenoma to adenocarcinoma. The functional roles of TP53 mutation in tumor development have been comprehensively investigated. In CRC, TP53 mutation was associated with poor prognosis and chemoresistance. A gain of function (GOF) of p53 mutants promotes cell proliferation, migration and invasion through multiple mechanisms. Restoring wild type p53 function, depleting p53 mutants, or intervention by targeting the oncogenic downstreams provides potential therapeutic strategies. In this review, we comprehensively summarize the GOF of p53 mutants in CRC progression as well as in some other solid tumors, and discuss the current strategies targeting p53 mutants in malignancies.
著者Li H, Zhang J, Tong JHM, Chan AWH, Yu J, Kang W, To KF
期刊名稱International Journal of Molecular Sciences
出版年份2019
月份12
日期1
卷號20
期次23
文章號碼5999
國際標準期刊號1661-6596
語言英式英語

上次更新時間 2020-26-10 於 00:11