Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors
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AbstractColorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in the world. It is a heterogeneous disease characterized by genetic and epigenetic aberrations. The TP53 mutation is the key step driving the transition from adenoma to adenocarcinoma. The functional roles of TP53 mutation in tumor development have been comprehensively investigated. In CRC, TP53 mutation was associated with poor prognosis and chemoresistance. A gain of function (GOF) of p53 mutants promotes cell proliferation, migration and invasion through multiple mechanisms. Restoring wild type p53 function, depleting p53 mutants, or intervention by targeting the oncogenic downstreams provides potential therapeutic strategies. In this review, we comprehensively summarize the GOF of p53 mutants in CRC progression as well as in some other solid tumors, and discuss the current strategies targeting p53 mutants in malignancies.
All Author(s) ListLi H, Zhang J, Tong JHM, Chan AWH, Yu J, Kang W, To KF
Journal nameInternational Journal of Molecular Sciences
Year2019
Month12
Day1
Volume Number20
Issue Number23
Article number5999
ISSN1661-6596
LanguagesEnglish-United Kingdom

Last updated on 2020-13-09 at 00:16